Group A  streptococci (Flesh-Eating B representeria)     INTRODUCTION  Group A  streptococcitococcus  eject normally be  prove in the  pharynx and on the  shinny. This  gallop of Strep causes mild to  disgustful  transmission systems  much(prenominal) as strep throat. A more  vinegarish strain of GAS causes necrotizing fasciitis. Invasive infections of GAS  be found in areas where the  bacterium is not   ordinarily present.  Streptococcus pyogenes infects the  horde by the following sequence of events.                    1.The  bacterium produces pyrogenic exotoxins A and or B, which  foundation be found in  wicked infections. The exotoxins are toxins that are released extracellularly as the organism grows. 2.The exotoxins and the surface M-proteins act as superantigens. Superantigens cause the host dam get on with by massive  arousal of the immune system. 3.The antigen binds to the Beta-chain of the T-cell receptor in a location that is not the normal binding site. 4.Leads to overru   n of T-cells in the area of bacterial  outgrowth 5.The T-cells secrete  elephantine amounts of effector cells causing inflammation,  wander   devastation, and  expiry in  roughly 30% of cases. This  weave destruction is what gives this strain of Strep the  cry  frame of reference-eating bacteria. The bacteria spread so  quickly because they secretes streptokinase, a fibrinolytic substance that dissolves clots that would  project otherwise prevented further growth and invasion.    NECROTIZING FASCIITIS  Necrotizing fasciitis is an infection of the soft tissue that causes necrosis of fascia and subcutaneous tissue. It  nigh commonly affects areas of the groin, abdomen, or extremities, but can  brush up almost anywhere. It is one of the  quick spreading infections known, and without treatment can lead to death.   The infection usually  fathers in the following  direction:  Opening in  kowtow is present Exposure to Strep Type A bacteria, usually an invasive strain bacteria grows and rel   eases toxins Discomfort in  neighbourhood wh!   ere bacteria  septic skin Pain worsens and flu-symptoms develop  field of force swells, becomes red, hot and  huffy Large, black blisters form as infection spreads and develops     The opening in the skin most often associated with flesh eating bacteria is some kind of minor hurt to the skin. Other possibilities  imply surgery, giving birth, or broken bones.  completely it can  lay claim is a little pinprick and the right conditions.  The  totally process occurs  at bottom a week and a  fewer have died in as few as 24 hours.  Therefore, time is of the  center of attention in diagnosing this infection in order to  fracture it before it progresses too   removedthermost.   WHO IS AT  guess?  Necrotizing fasciitis can develop in any person; yet those most at risk are:  Children younger than the age of ten  senior older than the age of 74 Those with  vestigial chronic illnesses such(prenominal) as cancer or  nubble disease.

    SYMPTOMS  Skin painful, red, hot,  futile Skin develops a violet  dirt with blisters Fever  fast heartbeat Sweating Chills Nausea  lightheadedness Weakness  offend Vomiting Diarrhea Dehydration  Necrotizing fasciitis can lead to death if it is untreated, but when diagnosed and treated this can be prevented. The sooner it is caught, the easier it is to treat. However, because most of its symptoms are flu-like, it can be  unwieldy to diagnose until it is  by and by on in the progress of the infection.         handling AND PREVENTION  When diagnosed  earlier it is possible to stop Necrotizing fasciitis. The treatment  inevitable depends on how far the infection has progressed. Possibilities include:  Pow   erful antibiotics  given over intravenously Drainage !   and removal of infected tissue Amputation of the infected  offshoot  There is no sure prevention of Necrotizing fasciitis,  so far there are ways one can   evanesce their risk:  Clean any skin injuries thoroughly and   harbour an antibiotic ointment. After a skin injury  be for symptoms and consult a doctor immediately if symptoms are observed. Be cautious of spreading any type of strep infection.    REFERENCES    civilisation on Group A Streptococci, from the Centers for Disease Control hypertext  transport protocol://www.cdc.gov/ncidod/dbmd/diseaseinfo/groupastreptococcal_g.htm Necrotizing Fasciitis of the Head and Neck, by Troy A. Callender, MD http://www.bcm.tmc.edu/oto/  insulting/123192.html                                          If you want to get a full essay, order it on our website: 
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